Biomed 2010

Frontiers in Biomedical Research

As Israel’s popular conference Biomed 2010 begins, we take a look at the biggest developments in Israel’s biotech industry over the last year.

A delivery system to fight the flu

Biopharmaceutical firm NasVax is making waves with its VaxiSome delivery system which helps boost the body’s response to a vaccine.

A meeting of biotech minds

Israel’s Biomed 2010 hosts top personnel from Roche, JP Morgan Chase and Johnson & Johnson, at an annual event where multi-million dollar pharmaceutical deals are made.

Moving closer to stem cell therapy

An Israeli discovery allowing stem cells to be cultivated in quantities ample enough to meet the world’s needs means that stem cell therapy could soon be within the reach of millions.

Israeli diagnostics company to buy up US technologies

It started life when the founder identified an unmet need in diagnostics. Now Israeli life science company Novamed is planning a spending spree – to buy up American companies and technologies.

Computerized discovery platforms find medical ‘gold’

A few months ago Israeli drug discovery company Compugen was in deep financial trouble. Now it’s staged a turnaround, attracting interest from international pharmaceutical giant, Pfizer.

A revolution in heart disease diagnosis

A new imaging device from Israel can capture a still image of a beating heart, providing early diagnosis of the world’s Number One killer disease.

Heart health at the tip of your finger

Israeli company Itamar Medical has developed a device that can measure the health of your heart from a fingertip test. Now the device has received a seal of approval from the Mayo Clinic.

Israeli company helps you get smart about your meds

Prescription drugs mixed inadvertently with over the counter medications can be a lethal cocktail hospitalizing hundreds of thousands of people every year. Now an Israel company has the solution.

Israeli company holds out promise of universal flu vaccine

As the World Health Organization declares swine flu a pandemic, an Israeli company has begun clinical trials of a universal flu vaccine that could protect against almost every type of flu virus.

Moving towards a treatment for Alzheimer’s

Ongoing research at an Israeli university may lead to vaccines that can teach our immune systems to better fight Alzheimer’s disease.

A new treatment for chronic wounds

Israel could become a leader in the $3 billion chronic wound industry with a new device that heals wounds faster and more cheaply than alternatives.

Scientists develop protein to regrow blood vessels

A new protein injection developed by Israeli researchers can trigger the regrowth of blood vessels around the heart, offering a potential alternative to risky bypass surgery.

Facing down the super-antigens

An Israeli biotech company is developing a new peptide that could be used to treat sepsis and septic shock by preventing a cascade of toxic super-antigens in the body.

A novel molecular approach to fighting cancer

At Israeli company Biokine Therapeutics, the focus from day one has been on finding drugs to fight cancer. Nine years on, the company believes it’s nearing its goal with a promising potential drug that can be adapted to treat a variety of different cancers, from leukemia, to myeloma, as well as inflammatory diseases.

Searching for a vaccine for rheumatoid arthritis

16.Personalized Medicine

16. Personalized Medicine

Coinciding with the substantial progress in the Human Genome Project in the late 1990s, a new term emerged as a prediction of the future of the pharmaceutical industry: personalized medicine. Personalized medicine reaffirms the confidence of the new predictive sciences, or -omic technologies, in regards to the tremendous clinical impact they will command. The theory of personalized medicine
involves the collection and analysis of a patient’s genotype as indication to predict disease pathogenesis, disease progression, patient response to medication/therapy, and possibly even recommendations for certain preventative measures. Pharmaceutical companies are then expected to provide chemother-
apies synthesized specifically for the indicated patient population or perhaps single individuals.

This concept of personalized medicine is doomed by
(1) the expectations of pharmaceutical companies to undergo such a dramatic paradigm shift
from production of blockbuster drugs to tailor-made therapeutics and
(2) the unavoidable inherent costs of the FDA regulatory compliance process (i.e.,drug discovery, preclinical and clinical trials) that is currently estimated to be 8 to 12 years and $800 million–plus!

Unfortunately, to invest such time and money to benefit such a small patient population or individual is not a reasonable proposition.Other approaches to personalized medicine may have more potential for
generating clinical success. As mentioned before, advancements in digital health may provide access to an incredible amount of raw patient data, through which global data-mining opportunities may offer extraction of trends with significant clinical relevance. Physicians may use computational algorithms to predict clinical outcomes for specific patients through the comparative analysis of enormous patient populations presenting with similar medical histories who have received different treatment strategies. Personalized medicine in this approach allows physicians to tailor make, or customize, medical treatment for patients based upon the successful administration of similar therapies given to representative patient populations. This theory of personalized medicine does not require pharmaceutical companies to dramatically alter their business models and also gives rise to a new sector of sophisticated data-mining medical device systems.

Advancements in biomedical nanotechnology may also influence future personalized medicine doctrine. A novel nanoinspired personalized medicine approach could utilize computation mathematical models and imaging modalities to offer pathophysiologically relevant patient information regarding numerous
physical features (i.e., vascular diameter and tortuosity, tumor vascular fenestration size, blood flow dynamics, etc.) for the development of nanotechnology drug delivery strategies. The multistage drug delivery strategy described previously is a perfect example. Rational design algorithms could be applied to predict the optimal design of particle vectors to control their ability to navigate within the microvasculature to seek diseased endothelial cells. A physiologic snapshot produced by contemporary medical imaging modalities could then provide the physical parameters to output personalized treatment options. The appropriate vectors could then be chosen from combinatorial libraries of FDA approved vectors and drugs; assuming of course that at that time, numerous particle vectors and drugs are available.

12.Neuroengineering :

12. Neuroengineering :

In the world of science there are always new and more advanced technologies introduced on an ongoing basis. A very popular topic of interest today is called neuro-engineering. Moving our brains beyond the connection it has to the body and extending its limitations by the use of computers is the idea behind neuro-engineering (Singer, 2007). A computerized brain chip that could make things happen with just thinking it. How could this ever be possible? The research that has been done thus far has proven that at a biological level, it can be done and is being done. As always, advances in such technologies have their pros and cons. We are no where near ready to begin experimenting with this type of technology but, extensive research has already proven that there are many possibilities. These possibilities could better the quality of life in humans.

How It Works
The more popular technology researched in the field of neuro-ngineering is Brain-Computer Interfacing. In one-way BCI, computers either accept commands from the brain or send signals to it (for example, to restore vision) but not both (Gibb, 2004). Two-way, BCI would allow brains and external devices to exchange information in both directions but have yet to be successfully implanted in animals or humans.

There are two major levels these interfaces apply to: peripheral, which are prosthetic limbs, and neural, where a specific computer chip is placed into contact with the brain. “A recent breakthrough in brain-interfacing described research in which monkeys controlled a robotic arm with thought alone” (Gibb, 2004).
What It Solves
Neural engineering is a discipline that uses engineering techniques to understand,repair, replace, enhance, or treat the diseases of neural systems. Neural engineers are uniquely qualified to solve design problems at the interface…
Source:http://www.oppapers.com/essays/Neuroengineering/192618

10.Bioelectric Phenomena :

10.BIOELECTRIC PHENOMENA :

Bioinstrumentation/Bioelectrical Systems: Focus includes medical devices, modeling of biological systems, in particular circuit analogies to the nervous system, bioelectric phenomena and signal processing. This track interfaces with electrical engineering.

9.Image processing:

9.Image processing:

From Wikipedia, the free encyclopedia
In electrical engineering and computer science, image processing is any form of signal processing for which the input is an image, such as photographs or frames of video; the output of image processing can be either an image or a set of characteristics or parameters related to the image. Most image-processing techniques involve treating the image as a two-dimensional signal and applying standard signal-processing techniques to it.
Image processing usually refers to digital image processing, but optical and analog image processing are also possible. This article is about general techniques that apply to all of them.

9.1 RADIATION IMAGING :

8.Signal Processing:

8.Signal Processing:

Signal processing involves the collection and analysis of data from patients or experiments in an effort to understand and identify individual components of the data set or signal. The manipulation and dissection of the data or signal provides the physician and experimenter with vital information on the condition of the patient or the status of the experiment. Biomedical engineers apply signal-processing methods to the design of medical devices that monitor and diagnose certain conditions in the human body.