Staying Young

ความรู้เกียวกับชีวเคมีในร่างกายของเรา ช่วยให้มนุษย์มีชีวิตที่ยืนยาวมากขึ้นจริงหรือไม่

PartStaying Young 1 – BBC Explorations

The human life span may soon be doubled. Some scientists are honing in on a genetic switch to turn off ageing. Others have discovered a hormone which is already producing startling results in the over fifties.

The human life span may soon be doubled. Some scientists are honing in on a genetic switch to turn off ageing. Others have discovered a hormone which is already producing startling results in the over fifties.
In the war against ageing we meet four extraordinary people who are fighting Time on various fronts. Diane, Donald, Debbie and Michael all have strategies to stay young and live longer. It’s a universal desire, and well do almost anything to achieve it, but no-one has yet found the elixir of youth. But now, as this programme reveals, science is unlocking the secrets of ageing.

In New York, fashion designer Diane Gilman believes she has found the answer. Its called human growth hormone. While we’re young and growing, human growth hormone helps the body to build muscle and repair tissue. By middle age, the body stops producing it altogether. At 56 Diane injects herself with enough human growth hormone to recreate the levels she had in her twenties. Her two shots a day cost of over $1,000 a month. Human growth hormone is still undergoing clinical trials, but Diane believes it is money well spent. For her, taking human growth hormone has turned back time. It’s her victory in the age wars.

Donald and Debbie are in good health and live the Californian dream. Yet they take over one hundred pills a day. This is how they’re fighting the age wars – with a complicated mix of vitamins and anti-oxidants. It’s to protect themselves against the ravages of oxygen. Donald and Debbie began their regime over a year ago. In this short time, they’re convinced that anti-oxidants have given them back the energy of their youth.

In London, Michael Young’s weapons arent anti-oxidant pills but a highly restricted vegetarian diet. Michael is 42 years old. He plans to diet for the rest of his life, eating fewer than 1500 calories a day. It seems an unlikely solution but this starvation regime already works for rats and mice. Seventy years ago scientists discovered that halving the diet of a lab rat can double its age. Michael hopes the same is true for humans.

Taking human growth hormone, swallowing over a hundred pills a day, a life-long starvation diet – they all have high risks, and most of us would prefer something less demanding. Could we not simply turn off the genetic switch that makes us grow old? We discover a scientist who believes this is precisely what she can do.

Part 2 Staying Young – BBC Explorations

Part 3 Staying Young – BBC Explorations

Part 4 Staying Young – BBC Explorations

Part 5 Staying Young – BBC Explorations

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Repair, Rebuild, Enhance People

Repair, Rebuild, Enhance People

We find ourselves at a pivotal moment in the history of humankind. Our body parts wear out as we age into our seventies and beyond. Now, as humankind enters a new millennium, the potential to substantially alter this scenario beckons. Tissue engineering,regenerative medicine and system biology may allow us to continuously replace tissues and organs. This talk discusses the potential of such tissue and organ replacement,summarizes current progress, addresses the industry needed to make this a reality and explores ethical issues such as living cosmetic enhancements that might be more ‘StarWars’ than modern human

Regenerative Medicine Advancing

Wednesday, July 8, 2009
Regenerative Medicine Advancing
Federal Telemedicine news
From > http://telemedicinenews.blogspot.com/2009/07/regenerative-medicine-advancing.html

Today, regenerative medicine research is dramatically trying to improve the survival and rehabilitation of soldiers who are wounded in combat. Critical issues in combat care include the effectiveness and shelf life of blood products, reducing wound infections,plus reconstructing bone, tissue, and facial structures. Army surgical research now concentrates on informatics, clinical trauma, and bioprosthetics. In general, the military’s science and engineering research programs are focused on designing the soldier system of the future to cross disciplinary boundaries, to focus onprotection, injury intervention and cure, and to improve human performance. Last year, the Department of Defense created the Armed Forces Institute ofRegenerative Medicine made up of two multi-institutional consortia with $85 million to fund the effort. One consortia led by Wake Forest University, and the University ofPittsburgh, and the other consortia led by Rutgers University and the Cleveland Clinic willmove forward on research efforts. The U.S. Army Institute of Surgical Research isworking with both groups.

Progress is being made. For example, the Wake Forest Institute for Regenerative Medicine has developed a computer-controlled system to build properly organized muscle tissue in the lab. To do this, human muscle cells are attached to strands of collagen or connective tissue. They are then subjected to cyclic stretching in a bioreactor, which simulates the conditions of the human body. The preconditioning allows the cells to align in one direction to form muscle bundles and function like normal muscle.

Also, Wake Forest and the McGowan Institute for Regenerative Medicine are working to develop clinical therapies over the next five years that will focus on burn repair, wound healing without scarring, craniofacial reconstruction, limb reconstruction, regeneration or transplantation, and compartment syndrome a condition related to inflammation after surgery or injuries.

To further address these regenerative research issues, the Center for Advanced Bioengineering for Soldier Survivability (CABSS) has been established in the College of Engineering (COE) at Georgia Tech. Research funds for CABSS will enable partnerships to develop to include investigators in regenerative medicine and cranial and maxillofacial surgery at Morehouse College of Medicine, Children’s Healthcare of Atlanta, Emory University, and the Medical College of Georgia. These education institutions will combine their expertise to work with the engineering faculty at Georgia Tech.

Priorities of CABSS involve doing research on the healing of segmental bone defects,improved healing of massive soft tissue defects, improved wound healing, tissue viability assessment, and wound irrigation. In addition, the Army is funding research to study demographic and injury data on the battlefield, long-term outcomes of casualties, how to improve pre-hospital care for orthopedic and craniofacial injuries, and how to develop novel light weight materials for use in integrated robotic prostheses.

There remains the critical need for technologies to transfer into medical products which are safe and effective. To accomplish these goals, research teams at CABSS will include clinicians with expertise in combat medical care, and biomedical engineers and bioscientists with industry and regulatory expertise to shorten the process from inventionto clinical use.

Dr. Barbara D. Boyan, COE Associate Dean for Research and Price Gilbert, Jr. Chair of Tissue Engineering is leading the new CABSS center. Funding is available from DOD’s Institute of Surgical Research, the Orthopedic Trauma Research Program, and the Armed Forces Institute of Regenerative Medicine, as well as from corporate partners. Dr. Boyan’s goal is to establish funding for developing new technologies. In addition to musculoskeletal tissues, CABSS will investigate the interface between materials and nerve cells to enable the development of robotic prostheses to integrate directly with thepatient’s tissues. To bring the research together, a coalition of universities, life sciences companies,healthcare investors and patient advocates with the common goal for advancing cell-based therapies all united on July 1, to launch the Alliance for Regenerative Medicine.

The organization located in Washington D.C., will promote regulatory, research, and study how reimbursement policies can help foster innovation in regenerative medicine.

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