How to Build a Human

How to Build a Human

A BBC series on the building blocks of our biology and the role of Stem Cells in the process of our creation. How our ability to use Stem Cells can change the medicine of tomorrow and the truly remarkable possibilities that Stem Cells hold.

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จับประเด็นสำคัญของเรื่อง ( Main Ideas of this story)

1.เป็นผลงานวิจัยของนักพันธุวิศวกรรมศาสาสตร์ ที่พบความลับของ ดีเอ็น เอ ซึ่งควบคุมรหัสพันธุกรรมของมนุษย์
2.พวกเขาพยายามจะสร้างชิ้นส่วนมนุษย์ขึ้นมาใหม่เพื่อทดแทนอวัยวะที่สูญเสียไป
3.ในอนาคตมีบางคนกลัวว่าพวกเขาจะสร้างมนุษย์พันธุ์ใหม่ขึ้นมาแทนที่พวกเรา แต่ปัจจุบันเขาสามารถสร้างทายาทของพวกเราในมดลูกเทียมได้แล้ว
4…..ยัง รอความเห็นของท่านนะคะ

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ขอเชิญทุกท่านที่มาอ่านบทความต่างๆที่นี่ จับประเด็นที่ท่านได้อ่านแล้วส่งความเห็นมาแลกเปลี่ยนความคิดกัน ได้โดย

> คลิกที่ ใส่ความเห็น(Coments) ของแต่ละบทความ

CREATION : How do you create a new human being?

Until now, there has only been one way: nature’s miracle of conception where sperm meets egg. We meet a woman who has become pregnant with triplets in the traditional way. But sperm are no longer essential and there is now another way: man’s miracle of cloning where skin cell meets egg. If this dream is realised, history will be changed. This is the story of the struggle to build humans. What are the building blocks of life? Can they be manipulated and will we eventually be able to outdo nature in building humans?

We follow Jose Cibelli who has been working into the early hours every night for two years in pursuit of an obsession. This is now a dream that may be realised tomorrow morning. Every night he practices cloning cows eggs to perfect his skills for cloning a human.

Cloning is an awesome science, which has produced often hysterical reactions around the world. But why should it? In rural Northern England, Sarah Waddington is also going to produce clones. But their clones were conceived entirely naturally – they are soon to become the parents of triplets.

Jose is only planning to clone a human to the point at which he has a week old embryo, because at this stage the embryo has an extraordinary power to heal many different kinds of trauma and disease. This is known as therapeutic cloning.

There are other people who want to use cloning to create living breathing human beings. Jamie is seven and has cerebral palsy and is likely to die before he is ten years old. His parents see cloning him as the only ‘cure’ for this. Is cloning the answer?

Jose Cibelli can create the miracle of fusion without sperm. He will take a skin cell from a man and use the DNA in that skin cell to produce an embryo. Scientists think that these cells could be used to cure broken spines, help people grow new organs and limbs and even help halt the ageing process. Jose hopes to produce the cloned embryos of people who desperately need his help.

Pablo Nauman is diabetic and he has to inject insulin every day in order to stay alive. If stem cells are injected into his pancreas they will become pancreatic cells and start producing insulin.

For the first time in history, this program shows an ordinary human skin cell injected into a human egg. Jose’s dreams about the potential of embryonic stem cells can only be realised if he gets the cells to divide.

These are the building blocks of life, and in the next program we look at how individual humans differ.

How to Build a Human – Creation 1 (BBC)

How to Build a Human – Creation 2(BBC)

How to Build a Human – Creation 3(BBC)

How to Build a Human – Creation 4 (BBC)

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students embed stem cells in sutures

Johns Hopkins biomedical engineering students embed stem cells in sutures

Johns Hopkins biomedical engineering students have demonstrated a practical way to embed a patient’s own adult stem cells in the surgical thread that doctors use to repair serious orthopedic injuries such as ruptured tendons. The goal, the students said, is to enhance healing and reduce the likelihood of re-injury without changing the surgical procedure itself.

The project team — 10 undergraduates sponsored by Bioactive Surgical Inc., a Maryland medical technology company — won first place in the recent Design Day 2009 competition conducted by the university’s Department of Biomedical Engineering. In collaboration with orthopedic physicians, the students have begun testing the stem cell-bearing sutures in an animal model, paving the way for possible human trials within about five years.

The corporate sponsor, Bioactive Surgical, developed the patent-pending concept for a new way to embed stem cells in sutures during the surgical process. The company then enlisted the student team to assemble and test a prototype to demonstrate that the concept was sound. The undergraduates performed this work during the yearlong Design Team course, required in the Biomedical Engineering major.

The students believe this technology has great promise for the treatment of debilitating tendon, ligament and muscle injuries, often sports-related, that affect thousands of young and middle-aged adults annually. “Using sutures that carry stems cells to the injury site would not change the way surgeons repair the injury,” said Matt Rubashkin, the student team leader, “but we believe the stem cells will significantly speed up and improve the healing process. And because the stem cells will come from the patient, there should be no rejection problems.”

Lew Schon, a leading Baltimore foot and ankle surgeon and one of the inventors of the technology, said, “These students have demonstrated an amazing amount of initiative and leadership in all aspects of this project, including actually producing the suture and designing the ensuing mechanical, cell-based and animal trials.” Schon, who also is an assistant professor of orthopedic surgery in the Johns Hopkins School of Medicine, added that “the students exceeded all expectations. They have probably cut at least a year off of the development time of this technology, and they are definitely advancing the science in this emerging area.”

“The students did a phenomenal job,” said Richard H. Spedden, chief executive officer of Bioactive Surgical.

Stem Cells in Thailand

นักกฎหมายชี้สเต็มเซลล์ไทยโฆษณาเกินจริง ทั้งที่ผลวิจัยยังไม่ชัด

Source From ผู้จัดการรายวัน

วช. ระดมความคิดนักวิจัย-นักกฎหมาย ร่วมกำหนดทิศทางวิจัยสเต็มเซลล์ในไทย เลขาฯ วช. ติงนักวิจัยไม่ควรพูดมาก หากยังไม่รู้จริง หวั่นทำให้ประชาชนเข้าใจผิด ด้านนักกฎหมายธรรมศาสตร์ระบุ เอกชนหลายรายโฆษณาเกินจริงว่ารักษาได้ด้วยสเต็มเซลล์ ทั้งที่ยังอยู่แค่ขั้นตอนวิจัย แต่กลับไม่บอกผู้เข้าร่วมตามตรง และยังไม่มีกฎหมายรองรับให้เอกชนทำวิจัยในคนได้

อ่านรายละเอียดต่อ @ Thai stem Cell Network > http://thscn.tkc.go.th/content.asp?pageid=Mw&directory=MTY3&parent=MA&lv=MA&lang=&content=NTM

Thai hospitals offer a radical stem cell therapy not approved in the US or Europe

101 East- Thai stem cell controversy- 31 Jan 08- Part 1

101 East- Thai stem cell controversy- 31 Jan 08- Part 2

ตัวอย่างการประชาสัมพันธ์ ของบริษัทในประเทศไทย

บริษัทของเราตั้งอยู่ที่ประเทศไทย มาเลเซีย และอินโดนีเซีย เป็นผู้นำในด้านการเก็บรักษา สเตมเซลล์และ เป็นศูนย์กลาง ในการบำบัดรักษาด้วยสเตมเซลล์ ด้วยบรรทัดฐานการทำงานอันมี มาตรฐานจึงไม่เป็นที่สงสัยว่า ทำไมคุณพ่อคุณแม่ส่วนใหญ่ จึงไว้วางใจสเตมไลฟ์

* ด้วยการทำงานที่ใส่ใจดูแลลูกค้าทุกคน และให้ความสำคัญที่สุดกับสเตมเซลล์ของ ลูกที่คุณรัก
* วางใจได้ในเทคโนโลยีอันทันสมัย กระบวนการทำงานที่ละเอียดทุกขั้นตอนตาม มาตรฐานซึ่ง ทางการแพทย์ให้การยอมรับ
* เชี่ยวชาญในการเก็บรักษาสเตมเซลล์ภายในห้องปฏิบัติการซึ่งใช้ระบบของราชวิทยาลัย อายุรเวชแห่งประเทศสหรัฐอเมริกาอันเป็นที่ยอมรับ
* เราเป็นบริษัทแห่งเดียวในประเทศไทยที่รับประกัน Stem Cells ของคุณ
* ด้วยบริการอันเป็นส่วนตัวตลอด 24 ชั่วโมง

* เจ้าหน้าที่ของเราผ่านการฝึกอบรมทางการแพทย์ระดับมืออาชีพ และยินดีที่จะให้คำปรึกษา กับลูกค้าทุกคนอย่างเป็นกันเอง
* FDA ให้การยอมรับในขบวนการเก็บรักษาสเตมเซลล์
* ฮอตไลน์ สายด่วน 24 ชั่วโมง โดยเจ้าหน้าที่ผู้เชี่ยวชาญ
* พร้อมที่จะติดต่อประสานงานกับผู้เชี่ยวชาญทางการแพทย์ในการนำสเตมเซลล์ไปใช้งาน
* ใช้ขบวนการจัดเก็บที่มั่นใจได้ว่าดีที่สุด
* มีบริการทดสอบการติดเชื้อของ Cord blood
* จัดเก็บสเตมเซลล์ในระดับนานาชาติ
* จัดบริการทั้งการเก็บ Cord blood stemcell(สเตมเซลล์จากรกและสายสะดือของทารกแรกเกิด) และ Adult stemcell(สเตมเซลล์ในผู้ใหญ่)

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JAMA report includes Dr. Burt explaining how treatment with own stem cells has patients not requiring any treatment for up to 3+ yrs (length of study). Resets immune system with own stem cells. (Video on JAMA website) Next trial phase currently recruiting (Brazil). Visit ClinicalTrials.gov for more information

Repair, Rebuild, Enhance People

Repair, Rebuild, Enhance People

We find ourselves at a pivotal moment in the history of humankind. Our body parts wear out as we age into our seventies and beyond. Now, as humankind enters a new millennium, the potential to substantially alter this scenario beckons. Tissue engineering,regenerative medicine and system biology may allow us to continuously replace tissues and organs. This talk discusses the potential of such tissue and organ replacement,summarizes current progress, addresses the industry needed to make this a reality and explores ethical issues such as living cosmetic enhancements that might be more ‘StarWars’ than modern human

Regenerative Medicine Advancing

Wednesday, July 8, 2009
Regenerative Medicine Advancing
Federal Telemedicine news
From > http://telemedicinenews.blogspot.com/2009/07/regenerative-medicine-advancing.html

Today, regenerative medicine research is dramatically trying to improve the survival and rehabilitation of soldiers who are wounded in combat. Critical issues in combat care include the effectiveness and shelf life of blood products, reducing wound infections,plus reconstructing bone, tissue, and facial structures. Army surgical research now concentrates on informatics, clinical trauma, and bioprosthetics. In general, the military’s science and engineering research programs are focused on designing the soldier system of the future to cross disciplinary boundaries, to focus onprotection, injury intervention and cure, and to improve human performance. Last year, the Department of Defense created the Armed Forces Institute ofRegenerative Medicine made up of two multi-institutional consortia with $85 million to fund the effort. One consortia led by Wake Forest University, and the University ofPittsburgh, and the other consortia led by Rutgers University and the Cleveland Clinic willmove forward on research efforts. The U.S. Army Institute of Surgical Research isworking with both groups.

Progress is being made. For example, the Wake Forest Institute for Regenerative Medicine has developed a computer-controlled system to build properly organized muscle tissue in the lab. To do this, human muscle cells are attached to strands of collagen or connective tissue. They are then subjected to cyclic stretching in a bioreactor, which simulates the conditions of the human body. The preconditioning allows the cells to align in one direction to form muscle bundles and function like normal muscle.

Also, Wake Forest and the McGowan Institute for Regenerative Medicine are working to develop clinical therapies over the next five years that will focus on burn repair, wound healing without scarring, craniofacial reconstruction, limb reconstruction, regeneration or transplantation, and compartment syndrome a condition related to inflammation after surgery or injuries.

To further address these regenerative research issues, the Center for Advanced Bioengineering for Soldier Survivability (CABSS) has been established in the College of Engineering (COE) at Georgia Tech. Research funds for CABSS will enable partnerships to develop to include investigators in regenerative medicine and cranial and maxillofacial surgery at Morehouse College of Medicine, Children’s Healthcare of Atlanta, Emory University, and the Medical College of Georgia. These education institutions will combine their expertise to work with the engineering faculty at Georgia Tech.

Priorities of CABSS involve doing research on the healing of segmental bone defects,improved healing of massive soft tissue defects, improved wound healing, tissue viability assessment, and wound irrigation. In addition, the Army is funding research to study demographic and injury data on the battlefield, long-term outcomes of casualties, how to improve pre-hospital care for orthopedic and craniofacial injuries, and how to develop novel light weight materials for use in integrated robotic prostheses.

There remains the critical need for technologies to transfer into medical products which are safe and effective. To accomplish these goals, research teams at CABSS will include clinicians with expertise in combat medical care, and biomedical engineers and bioscientists with industry and regulatory expertise to shorten the process from inventionto clinical use.

Dr. Barbara D. Boyan, COE Associate Dean for Research and Price Gilbert, Jr. Chair of Tissue Engineering is leading the new CABSS center. Funding is available from DOD’s Institute of Surgical Research, the Orthopedic Trauma Research Program, and the Armed Forces Institute of Regenerative Medicine, as well as from corporate partners. Dr. Boyan’s goal is to establish funding for developing new technologies. In addition to musculoskeletal tissues, CABSS will investigate the interface between materials and nerve cells to enable the development of robotic prostheses to integrate directly with thepatient’s tissues. To bring the research together, a coalition of universities, life sciences companies,healthcare investors and patient advocates with the common goal for advancing cell-based therapies all united on July 1, to launch the Alliance for Regenerative Medicine.

The organization located in Washington D.C., will promote regulatory, research, and study how reimbursement policies can help foster innovation in regenerative medicine.

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Lifts Stem Cell Ban

Obama Reverses Course, Lifts Stem Cell Ban
President Signs Executive Order Approving Federal Funds for Stem Cell Research
By DAN CHILDS and LISA STARK
March 9, 2009

In what has been interpreted as a direct rebuke of former President George W. Bush, President Obama said today that his administration would make “scientific decisions based on facts, not ideology.”
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ABC’s Jake Tapper and Lisa Stark report on embryonic stem cell research.

The president signed an executive order ending an 8½-year ban on federal funding for embryonic stem cell research, paving the way for a significant amount of federal funds to flow to science.

“At this moment, the full promise of stem cell research remains unknown, and it should not be overstated,” Obama said this morning before signing the order. “But scientists believe these tiny cells may have the potential to help us understand, and possibly cure, some of our most devastating diseases and conditions.”

The president’s speech was equal parts hope for the new research and support for the scientists involved in such work.

“Today, with the executive order I am about to sign, we will bring the change that so many scientists and researchers, doctors and innovators, patients and loved ones have hoped for, and fought for, these past eight years: We will lift the ban on federal funding for promising embryonic stem cell research,” Obama said. “We will vigorously support scientists who pursue this research. And we will aim for America to lead the world in the discoveries it one day may yield.”

White House officials have said that the president’s order will give the National Institutes of Health 120 days to develop ethical guidelines for the research.

The NIH said in a briefing today that they are currently looking for ways to streamline the research process and determine how quickly grant money can be made available. While most grant processes can take as long as nine months, which would delay funds reaching researchers for up to a full year, the NIH has indicated it will try to expedite the grant process to get money from the stimulus out quickly.

“Encompassed in [the executive order] will also be the requirements around guidelines that will be drafted by the NIH [National Institutes of Health] as they … work with others around the country to make sure we’re handling the issue responsibly,” said Melody Barnes, the director of the president’s Domestic Policy Council.

The president also signed a memorandum that Barnes says will “restore scientific integrity in government decision making.” It will help ensure public policy is “guided by sound scientific advice,” she said.

See more at > http://abcnews.go.com/Health/Politics/story?id=7023990&page=1
Suggested Links :

Stem Cell in Thailand > http://thscn.tkc.go.th/ เครือข่ายผู้สนใจงานด้านเซลล์ต้นกำเนิด

Stem Cell

Regenerative Medicine: Pathways to Cure – Version 2.0
The Alliance for Medical Research is pleased to present a new video explaining the benefits of Stem Cell Research.

The volatile debate over research with human embryonic stem cells and the political and ethical implications that surround it is discussed by UCSD and Salk Institute researchers. Topics include human reproductive and therapeutic cloning, cell transplantation therapy for diabetes, and the legal, political and ethical issues surrounding the use of human embryonic stem cells.

Stem Cell in Thailand

>http://thscn.tkc.go.th/ เครือข่ายผู้สนใจงานด้านเซลล์ต้นกำเนิด

>http://www.biotec.or.th/biotechnology-th/newsdetail.asp?id=1967 Stemcell @ Biotec Thailand